Invitrogen™ Apoptosis-Enhancing Nuclease Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA522208

Product Code. 13279458

Description

Recommended positive controls: HeLa, HepG2, Molt-4. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Apoptosis-Enhancing Nuclease (AEN) is a nuclear exonuclease that serves as a critical player in p53-mediated apoptosis. Induced by p53 in response to various DNA damage signals, AEN is involved in the degradation of cellular DNA during apoptosis. The nuclease activity of AEN contributes to the controlled dismantling of cellular components, ensuring that the apoptotic process leads to the efficient and timely removal of damaged or unwanted cells. Its expression regulation via phosphorylation highlights the intricacy of apoptotic signaling pathways and underscores the importance of AEN in maintaining genomic stability and preventing tumorigenesis.

Specifications

• Antigen: Apoptosis-Enhancing Nuclease
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AEN
• Gene Alias: 2700083B06Rik; AEN; aen {ECO:0000250; apoptosis enhancing nuclease; apoptosis-enhancing nuclease; apoptosis-enhancing nuclease {ECO:0000250; interferon stimulated exonuclease gene 20kDa-like 1; interferon stimulated exonuclease gene 20-like 1; interferon-stimulated 20 kDa exonuclease-like 1; interferon-stimulated 20 kDa exonuclease-like 1 {ECO:0000312; ISG20L1; pp12744; RGD:1305051}; RGD1305051; SBBI58; UniProtKB:Q8WTP8}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64782
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.9 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8WTP8
• Gene Symbols: AEN
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Apoptosis-enhancing nuclease. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG