SERPINC1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA529646

Product Code. 13443857

Description

Recommended positive controls: HCT116. Predicted reactivity: Human (92%), Mouse (87%), Rat (85%), Pig (86%), Sheep (85%), Rhesus Monkey (90%), Bovine (83%), Guinea pig (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

Specifications

• Antigen: SERPINC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Serpinc1
• Gene Alias: AI114908; antithrombin; Antithrombin 3; anti-thrombin 3; antithrombin III; antithrombin-III; AT3; At-3; AT3D; ATIII; hypothetical protein LOC540261; MGC22579; PRO0309; serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin C1; serpin family C member 1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C, member 1; Serpinc1; THPH7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 462
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P01008
• Gene Symbols: Serpinc1
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 233 of Human Antithrombin III
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG