Invitrogen™ AMPK gamma-1,2,3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA536314

Product Code. 15517621

Description

This antibody detects endogenous protein at a molecular weight of 38, 54 and 63 kDa. Purity is >95% by SDS-PAGE.

The 5-AMP activated protein kinase (AMPK), a member of the SNF1 (sucrose non fermentor) kinase family, is a heterotrimeric protein comprise of alpha (63 kDa), beta (30 kDa) and gamma (38 kDa) subunits. The alpha subunit is the catalytic subunit, while beta and gamma are non catalytic subunits (although they have been found to interact with the active subunit in liver). AMPK regulates fatty acid and sterol synthesis by phosphorylation of acetyl-CoA as well as cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase. AMPK is activated by AMP and can be also regulated by treatment with purified protein phosphatase in vitro.

Specifications

• Antigen: AMPK gamma-1,2,3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKAG1
• Gene Alias: 2410051C13Rik; 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase subunit gamma-2; 5'-AMP-activated protein kinase subunit gamma-3; 5'-AMP-activated protein kinase, gamma-1 subunit; 5-AMP-activated protein kinase, gamma-2 subunit; 5'-AMP-activated protein kinase, gamma-3 subunit; AA571379; AAKG; AAKG2; adenosine monophosphate-activated protein kinase gamma 2-subunit; AI854673; Amkg3; AMP-activated protein kinase gamma 3 subunit; AMP-activated protein kinase gamma subunit; AMP-activated protein kinase gamma2 subunit; AMP-activated protein kinase, noncatalytic gamma-1 subunit; ampk gamma; AMPK gamma 2; AMPK gamma1; AMPK- gamma1; AMPK gamma-1 chain; AMPK gamma2; AMPK- gamma2; AMPK gamma-2 chain; AMPK gamma3; AMPK- gamma3; AMPK gamma-3 chain; AMPK subunit gamma-1; AMPK subunit gamma-2; AMPK subunit gamma-3; AMPKg; Ampkg3; AMPKg3L; AMPKg3S; BB036179; CMH6; H91620p; Prkaac; Prkag1; PRKAG2; PRKAG3; Prkga1; Protein kinase AMP-activated gamma; protein kinase AMP-activated non-catalytic subunit gamma 1; protein kinase AMP-activated non-catalytic subunit gamma 2; protein kinase AMP-activated non-catalytic subunit gamma 3; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catatlytic subunit; WPWS
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108099, 19082, 241113, 25520, 301518, 373545, 51422, 53632, 5571
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O54950, P54619, P80385, Q8BGM7, Q91WG5, Q9UGI9, Q9UGJ0
• Gene Symbols: PRKAG1, PRKAG2, PRKAG3
• Immunogen: Synthetic peptide corresponding to amino acids 50-100 of human AMPK gamma1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG