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Adaptin δ Mouse anti-Human, Unlabeled, Clone: 18, BD
Mouse Monoclonal Antibody
£228.00
Specifications
| Antigen | Adaptin δ |
|---|---|
| Clone | 18 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15875879
|
BD Biosciences
611328 |
50 μg | |||||||
Description
Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1 through AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (γ, α, δ, ε and β1, β2, β3, β4, respectively) that are noncovalently linked to one medium chain (μ1, μ2, μ3, or μ4) and one small chain (σ1, σ2, σ3, or σ4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. In the AP-3 complex, adaptin δ contains an N-terminal “head” domain that has 25% identity with adaptins α and γ, while its C-terminal “hinge” and “ear” domains are two-fold larger and more divergent as compared to the same domains in adaptins α and γ. Adaptin δ is widely expressed and its mutation results in protein storage deficiencies within lysosomal-related organelles in platelets, melansomes, and synaptic vesicles
Host Species: Mouse
Clone: 18
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Adaptin δ aa. 627-731
Formula Weight [Chemical]: 160kDa
Immunofluorescence, Western Blotting
Specifications
| Adaptin δ | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 18 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human | |
| Human Adaptin δ aa. 627-731 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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