Invitrogen™ Anthrax Protective Antigen Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA141128

Product Code. 11538101

Description

Suggested positive control: PA recombinant protein.

Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.

Specifications

• Antigen: Anthrax Protective Antigen
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Alias: Anthrax PA
• Immunogen: Synthetic peptides corresponding to amino acids 186-192 of the Anthrax PA protein (approx. 83 kDa).
• Regulatory Status: RUO
• Target Species: Bacteria
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: Conc. Not Determined
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Host Species: Rabbit
• Quantity: 200 μL
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid