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Angiopoietin 2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA129640
Code : LE
Additional Details : Weight : 0.01000kg
Description
This antibody is specific for mouse Angiopoietin-2 (mAng-2). Partial cross-reactivity is observed with human Angiopoietin-1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.Specifications
Angiopoietin 2 | |
Polyclonal | |
Unconjugated | |
ANGPT2 | |
AGPT2; Ang2; Ang-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGPT2; endothelial growth factor; Tie2-ligand | |
Rabbit | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
80 mg/mL | |
whole serum diluted in 0.02M potassium phosphate with 0.15M NaCl and 0.1% sodium azide; pH 7.2 | |
O15123, O35608 | |
ANGPT2 | |
Synthetic peptide corresponding to a region near the N-terminus of mouse angiopoietin-2, conjugated to KLH | |
RUO | |
11601, 285 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |