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Invitrogen™ Androgen Receptor Recombinant Rabbit Monoclonal Antibody (PO00-29)
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Product Code. 17948832
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
17948832 100 μL 100µL
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Product Code. 17948832 Supplier Invitrogen™ Supplier No. MA550696

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Description

Rabbit Recombinant Monoclonal Antibody

Positive control: A549 cell lysate, K562 cell lysate, Rat testis tissue lysate, rat epididymis tissue, human prostate carcinoma tissue, human fallopian tube tissue. Predicted band size: 99 kDa Subcellular Location: Cytoplasm, Nucleus.

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Androgen Receptor
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone PO00-29
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene AR
Gene Accession No. P10275, P15207
Gene Alias AIS; Andr; androgen nuclear receptor variant 2; androgen receptor; androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; Ar; AR8; AR-A; AW320017; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; SBMA; SMAX1; TFM; Variant AR45
Gene Symbols AR
Host Species Rabbit
Immunogen Synthetic peptide within Human Androgen Receptor aa 300-400 (N terminal).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24208, 367
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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