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  6. androgen receptor Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

androgen receptor Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16861635 Shop All Proteintech Products
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20 μL
150 μL
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20µL
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16861635 20 μL 20µL
16851635 150 μL 150µL
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Product Code. 16861635 Supplier Proteintech Supplier No. 220891AP20UL

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Description

Rabbit Polyclonal Antibody

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy′s disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).

Specifications

Antigen androgen receptor
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.49 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene AR
Gene Accession No. P10275, P15207, P19091
Gene Alias AIS, androgen receptor, AR, DHTR, Dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Gene Symbols AR
Host Species Rabbit
Immunogen androgen receptor Fusion Protein Ag17291
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11835, 24208, 367
Target Species Mouse, Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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