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Amphiphysin Polyclonal Antibody, Invitrogen™
Goat Polyclonal Antibody
Brand: Invitrogen PA518513
Code : A0
Additional Details : Weight : 0.01000kg
Description
This antibody is predicted to react with canine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.Specifications
Amphiphysin | |
Polyclonal | |
Unconjugated | |
Amph | |
Amph; AMPH1; amphiphysin; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); amphiphysin 1; amphiphysin I; HGNC:471 | |
Goat | |
Antigen affinity chromatography | |
RUO | |
218038, 273 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunohistochemistry, Western Blot | |
0.5 mg/mL | |
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
P49418, Q7TQF7 | |
Amph | |
Synthetic peptide sequence (KRKDESRISKAE) corresponding to the internal amino acids of AMPH | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |