AMPD1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA555316

Product Code. 15703241

Description

Immunogen sequence: SETSSTKLSH IDEYISSSPT YQTVPDFQRV QITGDYASGV TVEDFEIVCK GLYRALCIRE KYMQKSFQRF PKTPSKYLRN IDGEAWVANE Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

AMP deaminase (AMPD) is an allosteric enzyme involved in the regulation of adenosine metabolism. It catalyzes a central reaction in purine nucleotide biosynthesis where AMP is deaminated to IMP, liberating ammonia. There are three functional isoforms of AMPD. AMPD1 (E.C. No 3.5.4.6.) is the skeletal muscle-specific isoform M located in type II muscle fibers, neuromuscular junctions and in capillaries. This protein is the predominant member of AMPD multi-gene family and is considered as the sensor of the cell’s changing energy requirements. AMPD1 deficiency causes irregular muscle metabolism due to lower rate of ATP degradation, phosphocreatine hydrolysis and accumulation of lactic acid. Mutated AMPD1 expression has been detected in neuromuscular disorders, exercise-induced skeletal muscle myopathies and congestive heart failures due to coronary artery diseases.

Specifications

• Antigen: AMPD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AMPD1
• Gene Alias: adenosine monophosphate deaminase 1; adenosine monophosphate deaminase 1 (isoform M); adenosine monophosphate deaminase-1 (muscle); AI553520; AMP deaminase 1; AMP deaminase isoform M; Ampd; Ampd01; AMPD1; Ampd-1; MAD; MADA; MMDD; myoadenylate deaminase; RATAMPD01; RP5-1000E10.1; skeletal muscle AMPD
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 270
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P23109
• Gene Symbols: AMPD1
• Immunogen: Recombinant protein corresponding to Human AMPD1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only