Invitrogen™ AMOT Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA540947

Product Code. 15504512

Description

Peptide sequence: TANKQLAEKE YEGSEDTRKT ISQLFAKNKE SQREKEKLEA ELATARSTNE Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%.

AMOT (Angiomotin) belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. AMOT plays a central role in tight junction maintenance via the complex formed with ARHGAP17 - which acts by regulating the uptake of polarity proteins at tight junctions. AMOT is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels.

Specifications

• Antigen: AMOT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AMOT
• Gene Alias: AMOT; Angiomotin; angiomotin p130 isoform; angiomotin p80 isoform; CAG-2; D0Kist1; KIAA1071; RGD1564027; si:dkey-13f9.6; Sii6; wu:fj21a07
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 154796
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q4VCS5
• Gene Symbols: AMOT
• Immunogen: Synthetic peptide directed towards the N-terminal of human AMOT (aa 517-566).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG