Amikacin disulfate, Thermo Scientific™

An aminoglycoside antibiotic derived from Kanamycin A

Brand:  Thermo Scientific Alfa Aesar J63862.14

Product Code. 15416019

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Amikacin disulfate is used as an aminoglycoside antibiotic derived from Kanamycin A, used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. It is commonly used in the treatment of drug-resistant mycobacteria. It is used to study organism-directed delivery of antibiotics as well as drug resistance.

Solubility
Soluble in water at 50mg/ml with warming

Notes
Potency: 674-786 micrograms per mg

Chemical Identifiers

• CAS: 39831-55-5
• Molecular Weight (g/mol): 781.75
• InChI Key: FXKSEJFHKVNEFI-GCZBSULCSA-N
• IUPAC Name: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4-{[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide; bis(sulfuric acid)

• Molecular Formula: C22H47N5O21S2
• MDL Number: MFCD00167475,MFCD00167475
• PubChem CID: 134129615
• SMILES: OS(O)(=O)=O.OS(O)(=O)=O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O

Specifications

• CAS: 39831-55-5
• Quantity: 25g
• MDL Number: MFCD00167475,MFCD00167475
• Merck Index: 14,405
• InChI Key: FXKSEJFHKVNEFI-GCZBSULCSA-N
• IUPAC Name: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4-{[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide; bis(sulfuric acid)
• PubChem CID: 134129615
• Chemical Name or Material: Amikacin disulfate

• Color: White
• Molecular Formula: C22H47N5O21S2
• Beilstein: 6172633
• Solubility Information: Soluble in water at 50mg/ml with warming
• SMILES: OS(O)(=O)=O.OS(O)(=O)=O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O
• Molecular Weight (g/mol): 781.75
• Formula Weight: 781.77

Safety and Handling

Product Identifier

• Amikacin disulfate

Signal Word

• Danger

Hazard Category

• Serious eye damage/eye irritation Category 1
• Skin sensitiser Category 1
• Specific target organ toxicity Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.
• H318-Causes serious eye damage.
• H372-Causes damage to organs.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : Amikacin sulfate