Invitrogen™ AMIGO3 Monoclonal Antibody (371301)

Rat Monoclonal Antibody

Brand:  Invitrogen™ MA524114

Product Code. 15573802

Description

In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse AMIGO2, recombinant human (rh) AMIGO1, or rhAMIGO2 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Amphoterin induced gene and ORF 3 (AMIGO3) is a gene located on chromosome 3p21.31, encoding a member of the AMIGO family of proteins involved in cell adhesion, axon guidance, and neuronal signaling. AMIGO3 is primarily expressed in the central nervous system, playing a crucial role in neural development and the maintenance of neural circuits. Functionally, AMIGO3 contributes to neuronal growth and synapse formation, impacting processes such as neural plasticity and signal transduction. The protein's activity facilitates interactions with other neuronal surface proteins, influencing axon pathfinding and connectivity. Aberrant expression or mutations in AMIGO3 have been linked to neurological disorders and neurodegenerative diseases, suggesting its significance in neural health and pathology. Research into AMIGO3 continues to explore its potential therapeutic applications in promoting neural repair and modulating synaptic functions, offering insights into strategies for addressing nervous system disorders.

Specifications

• Antigen: AMIGO3
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q8C2S7
• Gene Symbols: Amigo3
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse AMIGO3 Thr20-Pro378.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Frozen), Western Blot
• Clone: 371301
• Conjugate: Unconjugated
• Gene: Amigo3
• Gene Alias: adhesion molecule with Ig like domain 3; adhesion molecule with Ig-like domain 3; ALI3; alivin 3; alivin-3; AMIGO3; AMIGO-3; amigo3 {ECO:0000312; amphoterin induced gene and ORF 3; amphoterin-induced gene and ORF 3; amphoterin-induced protein 3; E430002N15Rik; EMBL:AAO48952.1, ECO:0000312; Kiaa1851; MGC120552; mKIAA1851; RGD:631413}; transmembrane protein AMIGO3; UNQ6084/PRO20089
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 320844
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized