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Tocris Bioscience™ AMG 853
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Product Code. 30000887
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 30000887

Brand: Tocris Bioscience™ 5701/10

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Description

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Also inhibits BRD4 (Kd = 170 nM). Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

CAS 1169483-24-2
Quantity 10 mg
Solubility Soluble to 100mM in DMSO and to 100mM in ethanol
Molecular Formula C28H27Cl2FN2O6S
Formula Weight 609.49
Purity >98%
Molecular Weight (g/mol) 609.49
Chemical Name or Material 5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl]
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