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Invitrogen™ AMBRA1 Polyclonal Antibody

Product Code. 12828692
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Quantity:
100 μg
Unit Size:
100µg
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12828692 100 μg 100µg
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Product Code. 12828692 Supplier Invitrogen™ Supplier No. PA520512

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20512 can be used with blocking peptide PEP-0632.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death. Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AMBRA1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene AMBRA1
Gene Accession No. A2AH22, Q9C0C7
Gene Alias 2310079H06Rik; A130023A14; AA474864; activating molecule in beclin-1-regulated autophagy; activating molecule in Beclin1-regulated autophagy; activating molecule in BECN1-regulated autophagy protein 1; AMBRA1; autophagy and beclin 1 regulator 1; autophagy/beclin 1 regulator 1; autophagy/beclin-1 regulator 1; AV021921; D030051N19Rik; DCAF3; DDB1 and CUL4 associated factor 3; hypothetical protein; hypothetical protein LOC517263; ischemia related factor NYW-1; Kiaa1736; mKIAA1736; Nyw1; WD repeat domain 94; WDR94
Gene Symbols AMBRA1
Host Species Rabbit
Immunogen An 18 amino acid peptide from near the amino terminus of human Ambra1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 228361, 55626, 59319
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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