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Alpha-Smooth Muscle Actin Polyclonal Antibody, Invitrogen™

Product Code. 11385833
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Quantity:
500 μL
Unit Size:
500µL
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11385833 500 μL 500µL
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Product Code. 11385833 Supplier Invitrogen Supplier No. PA516697

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Description

Rabbit Polyclonal Antibody

PA5-16697 targets Actin Smooth Muscle in IHC (P) applications and shows reactivity with Bovine, Chicken, Human, mouse, Non-human primate, Rabbit, and Rat samples. The PA5-16697 immunogen is a synthetic peptide from N-terminus of human alpha-smooth muscle isoform of actin.

Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actin being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. In particular, smooth muscle actin is an alpha actin that is found in skeletal muscle. Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. Smooth muscle actin is found on smooth muscle vessel walls, gut wall, myometrium, myoepithelial cells in breast and salivary glands. Defects in the smooth muscle actin gene cause aortic aneurysm familial thoracic type 6. Actin isoforms differ slightly in their N-terminus and the sequences of each are perfectly conserved in higher vertebrates. Alpha-smooth muscle actin is abundant in vascular and visceral smooth muscle cells. In addition, it has also been shown that smooth muscle actin appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases. Multiple alternatively spliced variants of smooth muscle actin have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Alpha-Smooth Muscle Actin
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide
Gene ACTA2
Gene Accession No. P62736
Gene Alias actin, aortic smooth muscle, alpha 2 actin, alpha-actin-2, alpha-cardiac actin, cell growth-inhibiting gene 46 protein, growth-inhibiting gene 46, alpha-sma
Gene Symbols ACTA2
Host Species Rabbit
Immunogen A synthetic peptide from N-terminus of human alpha-smooth muscle isoform of actin
Purification Method Affinity chromatography
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 59
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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