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alpha-2c Adrenergic Receptor Monoclonal Antibody (S330A-80), PerCP, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA545617

Additional Details : Weight : 0.01000kg

Product Code. 17838332

  • £362.00 / 100µg
Estimated Shipment: 19-08-2024
to see stock.

Description

Description

1 µg/mL of MA5-45617 was sufficient for detection of Alpha2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha- lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |Detects 50kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
Specifications

Specifications

alpha-2c Adrenergic Receptor
Monoclonal
1 mg/mL
2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
P18825, Q01337
ADRA2C
Synthetic peptide amino acids 442- 462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor
100 μg
Primary
Human, Mouse
Liquid
Immunocytochemistry, Western Blot
S330A-80
PerCP
ADRA2C
[a]2C; Adra 2c; ADRA2C; Adra-2c; ADRA2L2; ADRA2RL2; ADRARL2; Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic, alpha2C-, receptor class I; adrenoceptor alpha 2C; Alpha 2CAR; alpha-2 adrenergic receptor subtype C4; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; alpha2C; Alpha-2C adrenergic receptor; alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; alpha2-C4; alpha-2C-adrenergic receptor; ALPHA2CAR; alpha-2CAR; Alpha-2C-AR; subtype alpha2-C4
Mouse
Protein G
RUO
11553, 152
4° C
IgG1
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