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Invitrogen™ alpha-2b Adrenergic Receptor Monoclonal Antibody (5G10)
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Product Code. 11538213
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Quantity:
100 μg
Unit Size:
100µg
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11538213 100 μg 100µg
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Product Code. 11538213 Supplier Invitrogen™ Supplier No. MA112721

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Description

Mouse Monoclonal Antibody

A suggested positive control for this product is MDCK cells transfected with rat alpha2B adrenergic receptors.

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
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Specifications

Antigen alpha-2b Adrenergic Receptor
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 5G10
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.08% sodium azide
Gene ADRA2B
Gene Accession No. P19328, P30545
Gene Alias [a]2B; ADA2B; Adra2b; Adra-2b; ADRA2B adrenergic, alpha-2B-, receptor; ADRA2L1; ADRA2RL1; ADRARL1; Adrenergic alpha2B- receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor; Adrenergic, alpha2B-, receptor class III; adrenoceptor alpha 2B; alpha-2 adrenergic receptor subtype C2; alpha-2-adrenergic receptor-like 1; alpha2B; alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; alpha-2B adrenoreceptor; ALPHA2BAR; alpha-2BAR; alpha2-C2; FAME2; G-protein coupled receptor; subtype alpha2-C2
Gene Symbols ADRA2B
Host Species Mouse
Immunogen Synthetic peptide corresponding to the third intracellular loop of rat alpha 2b adrenergic receptor.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11552, 24174
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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