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  6. Invitrogen™ ALKBH2 Recombinant Rabbit Monoclonal Antibody (K01_1M58)

Invitrogen™ ALKBH2 Recombinant Rabbit Monoclonal Antibody (K01_1M58)

Product Code. 30828958
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Product Code. 30828958 Supplier Invitrogen™ Supplier No. MA564733
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Estimated Shipment: 23-09-2026
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: RKQEEQEPTG EEPAV.

The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALKBH2
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1M58
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 150mM NaCl, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene ALKBH2
Gene Accession No. Q6NS38, Q6P6J4
Gene Alias 2OG-Fe(II) oxy DC1; 9530023G02; Abh2; AlkB homolog 2; alkB homolog 2, alpha-ketoglutarate dependent dioxygenase; alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase; alkB, alkylation repair homolog 2; alkB, alkylation repair homolog 2 (E. coli); ALKBH2; Alkylated DNA repair protein alkB homolog 2; alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; AU016977; DNA oxidative demethylase ALKBH2; mABH2; oxy DC1; RGD1306377
Gene Symbols ALKBH2
Host Species Rabbit
Immunogen A synthetic peptide of human ALKBH2 (aa 15-29).
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 121642, 231642, 304578
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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