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Invitrogen™ ALKBH2 Polyclonal Antibody

Product Code. 12839152
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Quantity:
100 μg
Unit Size:
100µg
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12839152 100 μg 100µg
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Product Code. 12839152 Supplier Invitrogen™ Supplier No. PA521005

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human kidney tissue lysate. PA5-21005 can be used with blocking peptide PEP-1119.

The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALKBH2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ALKBH2
Gene Accession No. Q6NS38, Q6P6J4
Gene Alias 2OG-Fe(II) oxy DC1; 9530023G02; Abh2; AlkB homolog 2; alkB homolog 2, alpha-ketoglutarate dependent dioxygenase; alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase; alkB, alkylation repair homolog 2; alkB, alkylation repair homolog 2 (E. coli); ALKBH2; Alkylated DNA repair protein alkB homolog 2; alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; AU016977; DNA oxidative demethylase ALKBH2; mABH2; oxy DC1; RGD1306377
Gene Symbols ALKBH2
Host Species Rabbit
Immunogen A 15 amino acid peptide near the carboxy terminus of human ALKBH2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 121642, 231642, 304578
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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