Invitrogen™ Aldolase B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA551694

Product Code. 15739650

Description

Immunogen sequence: KPNMVTAGHA CTKKYTPEQV AMATVTALHR TVPAAVPGIC FLSGGMSEED ATLNLNAINL CPLPKPWKLS FSYGRALQAS ALAAWGGKAA NKEATQEAFM KRAMANCQAA KGQYVHTGSS GAA Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

Fructose-1,6-bisphosphate aldolase is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.

Specifications

• Antigen: Aldolase B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Aldob
• Gene Alias: ALDB; Aldo2; Aldo-2; ALDOB; Aldolase 2; aldolase 2, B isoform; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; aldolase, fructose-bisphosphate B; BC016435; Fructose-bisphosphate aldolase B; LIV10; Liver-type aldolase
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 229
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P05062
• Gene Symbols: Aldob
• Immunogen: Recombinant protein corresponding to Human Aldolase B. Recombinant protein control fragment (Product #RP-101633).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG