Invitrogen™ ALDH18A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA552546

Product Code. 15700501

Description

Immunogen sequence: SIVEQVSVLQ NQGREMMLVT SGAVAFGKQR LRHEILLSQS VRQALHSGQN QLKEMAIPVL EARACAAAGQ SGLMALYEAM FTQYSICAAQ ILVTNLDFHD EQKRRNLNGT LHELLRMNIV PIVNTNDAVV PPAEPNSDLQ GVNVISVKD Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

Specifications

• Antigen: ALDH18A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ALDH18A1
• Gene Alias: 2810433K04Rik; ADCL3; AI429789; aldehyde dehydrogenase 18 family member A1; aldehyde dehydrogenase 18 family, member A1; aldehyde dehydrogenase 18A1; aldehyde dehydrogenase family 18 member A1; aldh18a1; ARCL3A; cb842; cb899; delta1-pyrroline-5-carboxlate synthetase; delta-1-pyrroline-5-carboxylate synthase; delta-1-pyrroline-5-carboxylate synthetase; Gamma-glutamyl kinase; Gamma-glutamyl phosphate reductase; GK; Glutamate 5-kinase; glutamate gamma-semialdehyde synthetase; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GPR; GSAS; MGC117316; P5CS; Pycs; pyrroline-5-carboxylate synthetase; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase); sb:cb881; similar to pyrroline-5-carboxylate synthetase isoform 1; SPG9A; SPG9B; wu:fa91f10; wu:fi05f11; wu:fi17d12
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361755, 56454, 5832
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry, Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P54886, Q9Z110
• Gene Symbols: ALDH18A1
• Immunogen: Recombinant protein corresponding to Human ALDH18A1. Recombinant protein control fragment (Product #RP-89746).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG