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STEMCELL Technologies AKT Inhibitor X (Hydrochloride)

Product Code. 17130152
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10 mg
Unit Size:
10mg
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17130152 10 mg 10mg
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Product Code. 17130152 Supplier STEMCELL Technologies Supplier No. 72952

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Description

PI3K/AKT pathway inhibitor; Inhibits AKT

  • AKT Inhibitor X is a cell-permeable phenoxazine-derivative inhibitor of AKT kinase phosphorylation with an IC50 of ∼1 - 2 μM
  • AKT Inhibitor X blocks translocation of AKT after insulin-like growth factor 1 (IGF-1) treatment (Thimmaiah et al.) This product is supplied as the hydrochloride salt of the molecule
  • Inhibits growth and induces apoptosis of human rhabdomyosarcoma cell lines (Thimmaiah et al.)
  • Inhibits proliferation of breast cancer cell lines, alone or synergistically with chloroquine (Hu et al.)
  • Reduces replication of Myxoma virus in a variety of human tumor cell lines (Werden & McFadden)
  • Induces autophagy in neurons and is neuroprotective in a primary neuronal Huntington Disease cellular model (Tsvetkov et al.)

Specifications

CAS 925681-41-0
Synonym 10-DEBC hydrochloride
Quantity 10 mg
Molecular Formula C20H25ClN2O · HCl
Purity ≥95%
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