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Invitrogen™ Akirin1 Polyclonal Antibody

Product Code. 12818482
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12818482 100 μg 100µg
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Product Code. 12818482 Supplier Invitrogen™ Supplier No. PA520605

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Description

Rabbit Polyclonal Antibody

A suggested positive control is A549 cell lysate. PA5-20605 can be used with blocking peptide PEP-0725.

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Akirin1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene AKIRIN1
Gene Accession No. Q99LF1, Q9H9L7
Gene Alias 6330407G11Rik; akirin 1; AKIRIN1; akirin-1; C1orf108; Mighty; Mighty protein; MNCb-2831; RP11-781D11.2; STRF2
Gene Symbols AKIRIN1
Host Species Rabbit
Immunogen A 16 amino acid peptide near the amino terminus of the human Akirin1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 595134, 68050, 79647
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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