Akirin1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520606

Product Code. 12828482

Description

A suggested positive control is rat liver tissue lysate. PA5-20606 can be used with blocking peptide PEP-0726.

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Specifications

• Antigen: Akirin1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AKIRIN1
• Gene Alias: 6330407G11Rik; akirin 1; AKIRIN1; akirin-1; C1orf108; Mighty; Mighty protein; MNCb-2831; RP11-781D11.2; STRF2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 595134, 68050, 79647
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q99LF1, Q9H9L7
• Gene Symbols: AKIRIN1
• Immunogen: A 14 amino acid peptide near the center of the human Akirin1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG