AKAP13 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16865915	Proteintech 27947-1-AP-20UL	20 μL
16855915	Proteintech 27947-1-AP-150UL	150 μL

Description

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.

Specifications

• Antigen: AKAP13
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q12802
• Gene ID (Entrez): 11214
• Immunogen: AKAP13 Fusion Protein Ag27486
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: AKAP13

• Concentration: 0.33 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: A kinase anchor protein 13, AKAP 13, AKAP Lbc, AKAP13, ARHGEF13, BRX, c lbc, HA 3, Ht31, LBC, LBC oncogene, Lymphoid blast crisis oncogene, p47, PROTO LB, PROTO LBC
• Gene Symbols: AKAP13
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody