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AIRE Rat anti-Mouse, Alexa Fluor 488, Clone: 5H12, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-5934-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15342050

  • £237.85 / 100µg


EU Stock 2
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Disclaimers:

For Research Use Only.


Specifications

Description

This 5H12 monoclonal antibody reacts with mouse Autoimmune Regulator (AIRE). This 58kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs). However, expression of AIRE protein in the periphery remains unclear despite the detection of AIRE mRNA in the lymph node, lymphoid stromal cells, monocytes, and dendritic cells. Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection. Other biological functions for AIRE include chemokine expression and antigen presentation.

The 5H12 antibody recognizes mouse AIRE isoforms 1 and 2.
Description & Specifications

Specifications

AIRE
5H12
Alexa Fluor 488
Conjugated
Rat
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Immunohistochemistry (Frozen)
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Autoimmune Regulator
IgG2c
RUO
Primary
Murine