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Invitrogen™ AIM2 Polyclonal Antibody, eBioscience™
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Product Code. 15207697
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100 μL
Unit Size:
100µL
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15207697 100 μL 100µL
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Product Code. 15207697 Supplier Invitrogen™ Supplier No. 14600893

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Description

Rabbit Polyclonal Antibody

Description: This polyclonal antibody reacts with human, mouse, and rat AIM2 (also known as Antigen isolated from Immunoselected Melanoma 2). A member of the HIN-2000 family, this 40-kDa cytoplasmic protein is expressed in the spleen, small intestine, peripheral blood lymphocytes, and testis. Moreover, AIM2 is expressed in tumors of the neuroectodermis, breast, ovary, and colon. As a component of the inflammosome, AIM2 detects double-stranded viral and bacterial DNA present in the cytosol and initiates Caspase1 activation. Expression of AIM2 can be induced by interferons. Applications Reported: This polyclonal antibody has been reported for use in immunoblotting (WB). Applications Tested: This polyclonal antibody has been tested by immunoblotting of Jurkat cells and mouse macrophages treated for 12 hrs with IFN gamma and LPS. This can be used at less than or equal to a 1:1000 dilution. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AIM2
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 1mg/mL BSA and 0.05% sodium azide
Gene AIM2
Gene Accession No. O14862, Q91VJ1
Gene Alias Absent in melanoma 2; AIM2; Gm1313; Ifi210; ifi-210; Interferon-inducible protein 210; interferon-inducible protein AIM2; Interferon-inducible protein p210; PYHIN4; RP11-520H16.3
Gene Symbols AIM2
Host Species Rabbit
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 304987, 383619, 9447
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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