Learn More
AHR Monoclonal Antibody (4MEJJ), PE-Cyanine7, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 25-5925-80
Code : NEW
Additional Details : Weight : 0.09500kg
Description
The aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AhR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the Ah Receptor. Studies indicate that in non-ligand activated cells, AhR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). The AhR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.
AHR Monoclonal antibody specifically detects AHR in Mouse samples. It is validated for Flow Cytometry.Specifications
AHR | |
Monoclonal | |
0.2 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
P30561 | |
AHR | |
E. coli derived, His-tagged AHR (aa 443-805) | |
25 μg | |
Primary | |
Mouse | |
Antibody | |
IgG2a κ |
Flow Cytometry | |
4MEJJ | |
PE-Cyanine7 | |
AHR | |
Ah; Ah receptor; Ahh; Ahr; Ahre; AH-receptor; aromatic hydrocarbon receptor; aryl hydrocarbon receptor; aryl-hydrocarbon receptor; bHLHe76; Class E basic helix-loop-helix protein 76; dioxin receptor; In | |
Rat | |
Affinity chromatography | |
RUO | |
11622 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
For Research Use Only.