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Invitrogen™ AHNAK Recombinant Rabbit Monoclonal Antibody (PSH01-10)
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Product Code. 17930293
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Quantity:
100 μL
Unit Size:
100µL
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17930293 100 μL 100µL
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Product Code. 17930293 Supplier Invitrogen™ Supplier No. MA549610

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Description

Rabbit Recombinant Monoclonal Antibody

Sequence Similarities: 100% Mouse/Rat. Tissue Specificity: Low tissue specificity. Positive Control: Human lung carcinoma tissue, human brain tissue, mouse brain tissue, rat brain tissue, A431, HeLa, NIH/3T3. Subcellular Location: Nucleus. Predicted band size: 629 kDa.

AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AHNAK
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone PSH01-10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene AHNAK
Gene Accession No. Q09666
Gene Alias AHNAK; AHNAK 1; AHNAK nucleoprotein; AHNAK nucleoprotein (desmoyokin); AHNAK-related; AHNAKRS; Desmoyokin; DY6; MGC5395; Neuroblast differentiation-associated protein AHNAK; PM227; RGD1308572; UV118
Gene Symbols AHNAK
Host Species Rabbit
Immunogen Recombinant protein within human AHNAK aa 451-900/5,890.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 191572, 66395, 79026
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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