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Afatinib, MedChemExpress

Product Code. 16463748
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Product Code. 16463748 Supplier Medchem Express Supplier No. HY10261

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Description

MedChemExpress Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.

Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.

Specifications

Chemical Name or Material Afatinib
CAS 850140-72-6
Color White
Purity Grade Notes Research
Molecular Formula C24H25ClFN5O3
Quantity 10 mg
Synonym BIBW 2992
Solubility Information DMSO : 100 mg/mL (205.79 mM; Need ultrasonic)
SMILES O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C.[(E)]
Molecular Weight (g/mol) 485.94
Formula Weight 485.94
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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