Invitrogen™ Adrenomedullin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5140125

Product Code. 17864640

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: ADTARLDVAS EFRKKWNKWA LSRGKRELRM SSSYPTGLAD VKAGPAQTLI RPQDMKGASR S Highest antigen sequence indentity to the following orthologs: Rat - 64%, Mouse - 61%.

Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and in the maintenance of cardiovascular functioning. In hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions. ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and can exert central effects such as decreasing food ingestion.

Specifications

• Antigen: Adrenomedullin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADM
• Gene Alias: ADM; Adrenomedullin; AM; AMpreproadrenomedullin; Ap; H39316; PAMP; preproadrenomedullin; proadrenomedullin N-20 terminal peptide; ProAM N-terminal 20 peptide; ProAM-N20; RATAP
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 133
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P35318
• Gene Symbols: ADM
• Immunogen: Recombinant protein corresponding to Human ADM. Recombinant protein control fragment (Product #RP-109171).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG