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Adezmapimod, MedChemExpress

Product Code. 16474806
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Product Code. 16474806

Brand: Medchem Express HY10256

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Description

MedChemExpress Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator.

Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator.

Specifications

Chemical Name or Material Adezmapimod
CAS 152121-47-6
Color White
Purity Grade Notes Research
Molecular Formula C21H16FN3OS
Quantity 100 mg
Synonym SB 203580 RWJ 64809
Solubility Information DMSO : 50 mg/mL (132.47 mM; Need ultrasonic)
SMILES O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C
Molecular Weight (g/mol) 377.43
Formula Weight 377.43
Percent Purity 96.59%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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