Invitrogen™ ADAP Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA582934

Product Code. 16339894

Description

Immunogen sequence: RPFRVTGPNS SSGIQARKNL FNNQGNASPP AGPSNVPKFG SPKPPVAVKP SSEEKPDKEP KPPFLKPTGA GQRFGTPASL TTRDPEAKVG FLKPVGPKPI NLPKEDSKPT FPWPPGNKPS LHSVNQD Highest antigen sequence indentity to the following orthologs: Rat - 69%, Mouse - 69%.

The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.

Specifications

• Antigen: ADAP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FYB1
• Gene Alias: ADAP; adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; B630013F22Rik; Fyb; Fyb1; FYB-120/130; FYN binding protein; FYN binding protein (FYB-120/130); FYN binding protein FYB-130; FYN-binding protein; FYN-binding protein 1; FYN-T-binding protein; p120/130; p120/p130; PRO0823; RGD1563421; Slap130; SLAP-130; SLP-76-associated phosphoprotein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2533
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O15117
• Gene Symbols: FYB1
• Immunogen: Recombinant protein corresponding to Human FYB1. Recombinant protein control fragment (Product #RP-102114).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG