Invitrogen™ ADAMTSL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA521414

Product Code. 13228968

Description

Recommended positive controls: H1299. Predicted reactivity: Mouse (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ADAMTSL2, or A Disintegrin And Metalloproteinase with Thrombospondin Motifs Like 2, is a gene that codes for a secreted glycoprotein involved in the regulation of extracellular matrix (ECM) and associated proteases. The gene, initially identified by the Kazusa DNA Research Institute, plays a crucial role in various biological processes including ECM remodeling. Mutations or alterations in ADAMTSL2 are implicated in multiple diseases, including genetic disorders like geleophysic dysplasia and cancer. Its expression levels and genetic variants have been correlated with cancer progression, immune cell infiltration in tumors, and other pathological conditions like non-alcoholic steatohepatitis (NASH). ADAMTSL2 is a potential biomarker for disease prognosis and therapeutic targeting due to its significant role in ECM dynamics and disease pathology.

Specifications

• Antigen: ADAMTSL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADAMTSL2
• Gene Alias: a disintegrin and metalloproteinase; A930008K15Rik; ADAM; ADAMs; ADAMTS like 2; Adamtsl2; ADAMTSL-2; ADAMTS-like 2; ADAMTS-like protein 2; GPHYSD1; Kiaa0605; metalloendopeptidases; RGD1305459; Tcp1; TCP-1; TSP1-repeat-containing protein 1; TSP1-repeats containing protein; TSP1-repeats-containing protein 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 77794, 9719
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7
• Gene Accession No.: Q7TSK7, Q86TH1
• Gene Symbols: ADAMTSL2
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ADAMTSL2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG