Invitrogen™ ADAMTS8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA551350

Product Code. 15615275

Description

The antibody detects endogenous levels of total ADAMTS8 protein. Peptide sequence: THKYAPFIII GLHLALGIFS FTLDTWSTSR GDTAEILGSG AGIACGSHVT Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93% The antibody detects endogenous levels of total ADAMTS8 protein.

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.

Specifications

• Antigen: ADAMTS8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADAMTS8
• Gene Alias: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 8; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif 8; ADAM metallopeptidase with thrombospondin type 1 motif, 8; ADAMs; ADAM-TS 8; ADAMTS8; ADAM-TS8; ADAMTS-8; ADAMTS-8 precursor (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2); EC 3.4.24.14; EC 3.4.24.82; FLJ41712; metalloendopeptidases; METH2; METH-2; METH2ADAM-TS METH-8; METH-8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11095
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1.6 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9UP79
• Gene Symbols: ADAMTS8
• Immunogen: Synthetic peptide of human ADAMTS8.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG