Invitrogen™ ADAMTS10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA559109

Product Code. 15756971

Description

Immunogen sequence: SLIVMVLART ELPALRYRFN APIARDSLPP YSWHYAPWTK CSAQCAGGSQ VQAVECRNQL DSSAVAPHYC SAHSKLPK Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 94%.

ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer (1-3). Embryogenesis, morphological growth changes, inflammation, tumor invasion and metastasis involve the breakdown and remodeling of the extracellular matrix. This degradation is due to the family of enzymes known as the matrix metalloproteinases (MMPs), which are related to ADAMTS subtypes. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs (1-3). ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver (1-3). The human ADAMTS10 gene maps to chromosome 19p13.3 (4). The human ADAMTS19 gene maps to chromosome 5q31 (1,5).

Specifications

• Antigen: ADAMTS10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADAMTS10
• Gene Alias: 9430006O18; a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 10; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10; a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 10; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif 10; ADAM metallopeptidase with thrombospondin type 1 motif, 10; ADAMs; ADAM-TS 10; ADAMTS10; Adam-ts10; ADAMTS-10; AW045948; metalloendopeptidases; WMS; WMS1; zinc metalloendopeptidase; Znmp
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 81794
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H324
• Gene Symbols: ADAMTS10
• Immunogen: Recombinant protein corresponding to Human ADAMTS10. Recombinant protein control fragment (Product #RP-93161).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG