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Invitrogen™ ADAM17 Polyclonal Antibody
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Product Code. 12888082
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Quantity:
100 μg
Unit Size:
100µg
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12888082 100 μg 100µg
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Product Code. 12888082 Supplier Invitrogen™ Supplier No. PA519872

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Hela cell lysate. A 17 amino acid peptide near the carboxy terminus of human TACE. The PA5-19872 immunogen is located within the last 50 amino acids of TACE. Predicted molecular ~ 93kD. In Western blot applications, this antibody has been observed to detect a band at: 93-125kD (Post-modification: 9 N-linked glycosylation). Predicted species reactivity based on immunogen sequence: mouse (94.1%).

ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane bound precusor of TNF-alpha to its mature soluble form. ADAM 17 is responsbile for the proteolytical release of soluble JAM3 from endothelial cells surface and the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and the amyloid precursor protein. It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ADAM17
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ADAM17
Gene Accession No. P78536, Q9Z1K9
Gene Alias a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM; ADAM 17; ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 18; Adam17; ADAM18; ADAMs; CD156B; CD156b antigen; CSVP; Disintegrin and metalloproteinase domain-containing protein 17; metalloendopeptidases; NISBD; NISBD1; Snake venom-like protease; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme
Gene Symbols ADAM17
Host Species Rabbit
Immunogen A 17 amino acid peptide near the carboxy terminus of human TACE.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57027, 6868
Target Species Human, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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