Thermo Scientific™ Human ACVRL1 (ALK1), GST Tag Recombinant Protein

Product Code. 10487423

Brand: Thermo Scientific™ PV4883

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots; aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Catalytic.

Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1, similar to other type 1 receptors, has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2. Mutations in ACVRL1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

Specifications

• Accession Number: P37023
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris with 150mM NaCl, 0.5mM EDTA, 0.02% polysorbate 20, 50% glycerol, 2mM DTT and no preservative; pH 7.5
• Gene ID (Entrez): 94
• Molecular Weight (g/mol): 68.9 kDa
• Name: Human ACVRL1 (ALK1), GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: activin A receptor like type 1; activin A receptor type II-like 1; activin A receptor type IL; activin A receptor, type II-like 1; activin A receptor, type II-like kinase 1; Activin receptor like kinase 1; activin receptor-like kinase 1; activin receptor-like kinase-1; Acvrl1; Acvrlk1; AI115505; AI427544; ALK1; ALK-1; HHT; HHT2; ORW2; R3; R-3; Serine/threonine-protein kinase receptor R3; SETHKIR; SKR3; TGF-B superfamily receptor type I; TSR-I
• Common Name: ACVRL1
• Gene Symbol: ACVRL1
• KinaseFamily: STKR Kinase Family
• Protein Length: 139-503
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: 139-503
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Assay Entry: Biochemical binding/kinetic
• Kinase Group: Ser⁄Thr Kinases: TKL Group
• Shipping Condition: Dry Ice
• Target Entry: ACVRL1 (ALK1)
• Target Gene: activin A receptor type II-like 1
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Catalytic
• Form: Liquid
• Protein Subtype: Serine/Threonine Kinases
• Research Category: Signal Transduction