Invitrogen™ ACVR2B Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA120175

Product Code. 11536142

Description

Neutralization: when used at a 1-3 μg/mL this antibody will block 50% of the binding of 30 ng/mL recombinant human activin A to immobilized recombinant human activin receptor IIB/Fc chimera (100 μL of a 0.5 μg/mL solution coating each well) in an ELISA assay.

ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.

Specifications

• Antigen: ACVR2B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACVR2B
• Gene Alias: activin A receptor type 2B; activin A receptor type IIB; activin A receptor, type IIB; activin receptor IIB; activin receptor type IIB; Activin receptor type-2B; Activine receptor 2b (transmembrane serine kinase); ActRIIB; ACTR-IIB; ActRIIB type II activin receptor B; ACVR2B; HTX4; MGC116908
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 93
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q13705
• Gene Symbols: ACVR2B
• Immunogen: Purified, NSO-derived, recombinant human activin receptor IIB extracellular domain.
• Quantity: 25 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG