Invitrogen™ ACVR1C Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5102319

Product Code. 16638794

Description

Antibody detects endogenous levels of total ACVR1C.

ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.

Specifications

• Antigen: ACVR1C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACVR1C
• Gene Alias: activin A receptor type 1C; activin A receptor type IC; activin A receptor, type IC; activin receptor type IC; Activin receptor type-1C; activin receptor-like kinase 7; ACTRI; ACTR-IC; ACVR1A; acvr1c; acvr1c {ECO:0000312; ACVRLK2; ACVRLK7; ALK2; Alk7; ALK-7; C230097P10; EMBL:AAC52803.1}; FOP; habrec1; SKR1; TGF-beta type 1 receptor; TSRI
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 130399, 245921, 269275
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P70539, Q8K348, Q8NER5
• Gene Symbols: ACVR1C
• Immunogen: A synthesized peptide derived from human ACVR1C(Accession Q8NER5), corresponding to amino acid residues P417-A467.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG