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Invitrogen™ ACVR1B Polyclonal Antibody

Product Code. 12838772
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Quantity:
100 μg
Unit Size:
100µg
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12838772 100 μg 100µg
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Product Code. 12838772 Supplier Invitrogen™ Supplier No. PA520596

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human kidney tissue lysate. PA5-20596 can be used with blocking peptide PEP-0716.

ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACVR1B
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ACVR1B
Gene Accession No. P36896, Q61271
Gene Alias 6820432J04; activin A receptor type 1B; activin A receptor type IB; activin A receptor, type 1B; activin A receptor, type IB; activin A receptor, type II-like kinase 4; activin receptor type IB; Activin receptor type-1B; activin receptor-like kinase 4; ACTRI; ActRIB; ActR-IB; ACVR1A; Acvr1b; ACVRLK2; ACVRLK4; ALK2; Alk4; ALK-4; FOP; Serine/threonine-protein kinase receptor R2; SKR1; SKR2; TSRI
Gene Symbols ACVR1B
Host Species Rabbit
Immunogen A 14 amino acid peptide near the carboxy terminus of the human ACVR1B.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11479, 91
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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