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ACTH Antibody (CLIP/1418), FITC - C-terminus, Novus Biologicals™

Product Code. 18335951 Shop All Bio Techne Products
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Product Code. 18335951 Supplier Novus Biologicals Supplier No. NBP280545F

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Description

Mouse Monoclonal Antibody

ACTH Monoclonal specifically detects ACTH in Human samples. It is validated for ELISA.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACTH
Applications ELISA
Classification Monoclonal
Clone CLIP/1418
Conjugate FITC
Formulation PBS
Gene Alias ACTH, adrenocorticotropic hormone, adrenocorticotropin, alpha-melanocyte-stimulating hormone, alpha-MSH, beta-endorphin, beta-LPH, beta-melanocyte-stimulating hormone, beta-MSH, CLIP, corticotropin-like intermediary peptide, corticotropin-lipotropin, gamma-LPH, gamma-MSH, lipotropin beta, lipotropin gamma, LPH, melanotropin alpha, melanotropin beta, melanotropin gamma, met-enkephalin, MSH, NPP, POC, pro-ACTH-endorphin, proopiomelanocortin, pro-opiomelanocortin, proopiomelanocortin preproprotein
Host Species Mouse
Immunogen Synthetic peptide corresponding to aa25-39 of human ACTH (NGAEDESAEAFPLEF) (Uniprot: P01189)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) 5443
Test Specificity ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This monoclonal antibody is specific to CLIP (aa25-39 of ACTH); does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. '
Target Species Human
Content And Storage Store at 4°C in the dark.
Form Purified
Isotype IgG1 κ
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