Invitrogen™ ACOT2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584443

Product Code. 16341395

Description

Immunogen sequence: MSNKLLSPHP HSVVLRSEFK MASSPAVLRA SRLYQWSLKS SAQFLGSPQL RQVGQIIRVP AR Highest antigen sequence indentity to the following orthologs: Mouse - 29%, Rat - 32%.

Acyl-CoA thioesterases (ACOTs) are a group of enzymes that catalyze the hydrolysis of acyl-CoA to form coenzyme A (CoA) and a free fatty acid. Through their catalytic activity, ACOTs are able to regulate the level of fatty acids and acyl-CoAs within the cell. ACOT1 (acyl-CoA thioesterase 1, also known as CTE1) and ACOT2 (acyl-CoA thioesterase 2, also known as PTE2) are members of the ACOT family and exhibit different cellular localization, with ACOT1 existing as a monomer in the cytoplasm and ACOT2 localized primarily to mitochondria. Characteristic of most ACOT proteins, ACOT1 and ACOT2 catalyze the conversion of Palmitoyl-CoA and water to free CoA and palmitate, a reaction that is important for the regulation of intercellular fatty acid levels. ACOT2 is expressed as multiple alternatively spliced isoforms and, like ACOT1, is encoded by a gene which maps to human chromosome 14.

Specifications

• Antigen: ACOT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACOT2
• Gene Alias: AA571646; Acot2; Acyl coenzyme A thioester hydrolase; acyl-CoA thioesterase 2; Acyl-coenzyme A thioester hydrolase 2a; acyl-coenzyme A thioesterase 2, mitochondrial; ARTISt/p43; CTE Ia; CTE1A; CTE-Ia; long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; Mte1; MTE-I; peroxisomal long-chain acyl-coA thioesterase 2; PTE2; PTE2A; Very-long-chain acyl-CoA thioesterase; ZAP128
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10965
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P49753
• Gene Symbols: ACOT2
• Immunogen: Recombinant protein corresponding to Human ACOT2. Recombinant protein control fragment (Product #RP-108217).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG