Invitrogen™ ACMSD Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA590853

Product Code. 16568021

Description

Immunogen sequence: MKIDIHSHIL PKEWPDLKKR FGYGGWVQLQ HHSKGEAKLL KDGKVFRVVR ENCWDPEVRI REMDQKGVTV QALSTVPVMF SYWAKPEDTL NLCQLLNNDL ASTVVSYPRR FVGLGTLPMQ APELAVKEME RCVKELGFPG VQIGTHVNEW DLNAQELFPV YAAAERLKCS LFVHPWDMQM DGRMAKYWLP WLVGMPAETT IAICSMIMGG VFEKFPKLKV CFAHGGGAFP FTVGRISHGF SMRPDLCAQD NPMNPKKYLG SFYTDALVHD PLSLKLLTDV IGKDKVILGT DYPFPLGELE PGKLIESMEE FDEETKNKLK AGNALAFLGL ERKQFE; Positive Samples: Mouse kidney, Mouse liver, Rat kidney.

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004].

Specifications

• Antigen: ACMSD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACMSD
• Gene Alias: 2-amino-3-carboxylmuconate-6-semialdehyde decarboxylase; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Acmsd; amino carboxymuconate semialdehyde decarboxylase; aminocarboxymuconate semialdehyde decarboxylase; Picolinate carboxylase; zgc:162888
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171385, 266645
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.38 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8R519, Q8R5M5
• Gene Symbols: ACMSD
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human ACMSD (NP_6121992).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG