Invitrogen™ Acid Phosphatase 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA582558

Product Code. 16309524

Description

Immunogen sequence: ENWRVDSAAT SGYEIGNPPD YRGQSCMKRH GIPMSHVARQ ITKEDFATFD YILCMDESNL RDLNRKSNQV KTCKAKIELL GSYDPQKQLI IEDPYYGNDS DFETVYQ Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 89%.

Low molecular weight protein tyrosine phosphtases, including the human red cell phosphatase, HCPTP, are widely expressed cytosolic proteins of approximately 18 kDa that exist in distinct isoforms and are highly selective for phosphotyrosine over phosphoserine or phosphotyrosine. The HCPTP-A and HCPTP-B proteins expressed in human red cells and placenta are fast and slow forms of red cell acid phosphatase5. Like other tyrosine phosphatases, HCPTP is sensitive to inhibition by vanadate, and has a catalytic mechanism that involves formation of a cystinylphosphate intermediate6. The crystal structure of the bovine heart derived enzyme BHPTP shows a four-stranded central parallel b sheet with flanking a helices and an active site cysteine residue in the typical tyrosine phosphatase sequence context, CXXXXXR.

Specifications

• Antigen: Acid Phosphatase 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACP1
• Gene Alias: 4632432E04Rik; acid phosphatase; acid phosphatase 1; acid phosphatase 1, soluble; acid phosphatase of erythrocyte; acp1; Acp-1; Acp1-PA; adipocyte acid phosphatase; Adult cuticle protein 1; AI427468; CG7216; CG7216-PA; cytoplasmic phosphotyrosyl protein phosphatase; Dacp-1; Dmel\CG7216; Dmel_CG7216; HAAP; HAAP betaÊ; hypothetical protein; LMW-PTP; LMW-PTPase; LMW-PTP-I low molecular weight phosphotyrosine protein phosphatase isozyme 1; Low molecular weight cytosolic acid phosphatase; low molecular weight phosphotyrosine protein phosphatase; MGC111030; MGC3499; phosphatase 1, soluble; protein tyrosine phosphatase; ptpase; RCJMB04_11a4; Red cell acid phosphatase 1; RH03221p; testicular secretory protein Li 37; Unknown (protein for MGC:128334)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11431, 24161, 52
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P24666, P41498, Q9D358
• Gene Symbols: ACP1
• Immunogen: Recombinant protein corresponding to Human ACP1. Recombinant protein control fragment (Product #RP-91565).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG