Invitrogen™ Acetyl-CoA Carboxylase Recombinant Rabbit Monoclonal Antibody (5J4W7)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA542717

Product Code. 17739313

Description

Positive test controls include: HeLa, HepG2, C6, Mouse liver, Mouse heart. Immunogen sequence: RLAKQSRHLE VQILADQYGN AISLFGRDCS VQRRHQKIIE EAPATIATPA VFEHMEQCAV KLAKMVGYVS AGTVEYLYSQ DGSFYFLELN PRLQVEHPCT E.

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Specifications

• Antigen: Acetyl-CoA Carboxylase
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P11497, Q13085, Q5SWU9
• Gene Symbols: Acaca, ACC
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human ACC1 (Q13085).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 5J4W7
• Conjugate: Unconjugated
• Gene: Acaca
• Gene Alias: A1Z784_DROME; A530025K05Rik; Acac; Acaca; ACACAD; Acc; ACC1; ACCA; ACC-alpha; ACC-PA; ACC-PB; ACC-PC; ACC-PE; ACC-PF; ACC-PG; aceto-acetyl-CoA-thiolase; acetyl CoA carboxylase; acetyl coenzyme A carboxylase; Acetyl-CoA carboxylase; Acetyl-CoA carboxylase 1; acetyl-CoA carboxylase 265; acetyl-CoA carboxylase alpha; acetyl-CoA-carboxylase; acetyl-coenzyme A carboxylase; acetyl-coenzyme A carboxylase alpha; ACoT; Biotin carboxylase; CG11198; CG11198-PA; CG11198-PB; CG11198-PC; CG11198-PE; CG11198-PF; CG11198-PG; CG8723; dACC; DmACC; Dmel\CG11198; Dmel_CG11198; EC 6.3.4.14; EC 6.4.1.2; FBgn0043811; GH12002p; Gm738; I79_006999; unnamed protein product
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 104371, 107476, 31, 60581
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid