Invitrogen™ ACER3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584834

Product Code. 16331785

Description

Immunogen sequence: DREGYWGPTT STLDWCEENY SVTWYIAEFW NTVSNLIMII PPMFGAVQSV RDGLEKR Highest antigen sequence indentity to the following orthologs: Mouse - 82%, Rat - 82%.

ACER3 is a protein coding gene. Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response.

Specifications

• Antigen: ACER3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACER3
• Gene Alias: 1110057L18Rik; 5430429L08Rik; Acer3; alkaline CDase 3; alkaline ceramidase 3; Alkaline dihydroceramidase SB89; alkaline phytoceramidase; AlkCDase 3; aPHC; AV015045; Phca; phytoceramidase, alkaline; RGD1561254
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55331
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NUN7
• Gene Symbols: ACER3
• Immunogen: Recombinant protein corresponding to Human ACER3. Recombinant protein control fragment (Product #RP-108561).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG