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Invitrogen™ ACE2 Polyclonal Antibody

Product Code. 15527982
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Quantity:
100 μg
Unit Size:
100µg
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15527982 100 μg 100µg
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Product Code. 15527982 Supplier Invitrogen™ Supplier No. PA547488

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Description

Goat Polyclonal Antibody

In Western blots, approximately 40% cross-reactivity with recombinant human ACE-2 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACE2
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene ACE2
Gene Accession No. Q5EGZ1, Q8R0I0, Q9BYF1
Gene Alias 2010305L05Rik; ACE 2; Ace2; ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; anigotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; Processed angiotensin-converting enzyme 2; renal angiotensin-converting enzyme 2; UNQ868/PRO1885
Gene Symbols ACE2
Host Species Goat
Immunogen CHO-derived recombinant mouse ACE-2 Gln18-Thr740.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 302668, 59272, 70008
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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