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  6. Invitrogen™ ACAP2 Recombinant Rabbit Monoclonal Antibody (K01_1P49)

Invitrogen™ ACAP2 Recombinant Rabbit Monoclonal Antibody (K01_1P49)

Product Code. 30828070
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30828070 50 μL
30828655 100 μL
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Product Code. 30828070 Supplier Invitrogen™ Supplier No. MA565147

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: RGANQHATDE EGKDP.

ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACAP2
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1P49
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 0.05% BSA, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene ACAP2
Gene Accession No. Q15057, Q5FVC7
Gene Alias 4832442G16; 9530039J15Rik; ACAP2; Arf GAP with coiled coil, ANK repeat and PH domains 2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; centaurin beta2; centaurin, beta 2; centaurin-beta-2; Centb2; CNT-B2; KIAA0041; mKIAA0041
Gene Symbols ACAP2
Host Species Rabbit
Immunogen A synthetic peptide of human Centaurin beta 2 (aa 696-710).
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100760438, 23527, 619382
Target Species Human, Rat, Hamster
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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